DASGIP® Parallel Bioreactor Systems

DASGIP® Parallel Bioreactor Systems
DASGIP® Parallel Bioreactor Systems
DASGIP® Parallel Bioreactor Systems
DASGIP® Parallel Bioreactor Systems
DASGIP® Parallel Bioreactor Systems
DASGIP® Parallel Bioreactor Systems

Eppendorf DASGIP Parallel Bioreactor Systems are designed to deliver optimal bioprocess performance in benchtop configurations. Scalable monitoring and control functionality enable users to achieve valid and reproducible results in an economical manner. Their modular design addresses the unique requirements of various applications in both cell culture and microbiology. More information

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Product Information

DASGIP Parallel Bioreactor Systems for R&D and process development in both cell culture and microbiology allow for advanced bioprocess control and automation. Parallel processing, precise control of all relevant parameters, user-defined profiles and innumerable automation features result in accelerated and highly efficient process development. Our DASware software solutions support DoE, process historians and comprehensive data management. Configurable solutions address the unique requirements of microbial, phototrophic, mammalian and human cells, stem cell applications, as well as biofuel and biopolymer processes.

Features

  • Parallel operation of up to 16 glass or single-use bioreactors
  • DASGIP Bioblock for advanced and user-friendly temperature control
  • Suitable for cell culture, microbial fermentation and phototrophic cultivation
  • Modular design of control units allows for flexible system configurations that meet the demands of specific applications
  • Control of agitation, pH, level and DO (including customizable cascade modes) in each bioreactor
  • Variable speed pumps for accurate liquid addition and operation in batch, fed-batch, continuous and cyclic perfusion mode
  • Optical absorbance measurement for online calculation of e.g. OD600 or cell dry weight
  • TMFC individual gas mixing of air, N2, O2 and CO2
  • Online calculation of OTR, CTR and RQ
  • DASware control Software for advanced process control
  • Compatible with DASware Software Suite for interconnectivity and bioprocess information management

Applications

  • Research and development in cell culture and microbiology as well as phototrophic applications
  • Lab scale fermentation of aerobic and anaerobic bacteria, yeasts and fungi
  • Cultivation of mammalian, insect and human cell lines
  • Special applications such as stem cell culture or biofuel/biopolymer development
 DASGIP® System for Cell CultureDASGIP® System for MicrobiologyDASGIP® PhotoBioreactor System
ApplicationCell culture2MicrobiologyPhototrophic cultivation
Number of parallel unitsUp to 16Up to 16Up to 16
SoftwareDASware control, other DASware optionalDASware control, other DASware optionalDASware control, other DASware optional
User InterfaceProcess computer with monitorProcess computer with monitorProcess computer with monitor
Typical power consumption (4-fold system without process computer)480 W (at 230 V)/
432 W (at 115 V)
(595 W/552 W without DASGIP Bioblock)
541 W (at 230 V)/
467 W (at 115 V)
(639 W/584 W without DASGIP Bioblock)
490 W (at 230 V)/
441 W (at 115 V)
(605 W/561 W without DASGIP Bioblock)
Dimensions (W × D × H, 4-fold system without process computer)140 x 70 x 53 cm (55 x 28 x 21 in)140 x 70 x 53 cm (55 x 28 x 21 in)140 x 70 x 53 cm (55 x 28 x 21 in)
Typical weight (4-fold system without accessories)78 kg
(60 kg without DASGIP Bioblock)
96 kg
(78 kg without DASGIP Bioblock)
77 kg
(59 kg without DASGIP Bioblock)
Bioreactors   
VesselsGlass/single-use vesselsGlass/single-use vesselsGlass vessels
SterilizationAutoclavable/
pre-sterilized
Autoclavable/
pre-sterilized
Autoclavable
Total volume1.5 L to 4.3 L1.3 L to 4.3 L1.9 L / 3.0 L
Agitation   
DriveDirect/magnetic overhead driveDirect/magnetic overhead driveDirect overhead drives
Speed ranges30 – 1,250 rpm (standard)/
100 – 1,600 rpm (optional)
100 – 1,600 rpm (standard)/
30 – 1,250 rpm (optional)
30 – 1,250 rpm (standard)/
100 – 1,600 rpm (optional)
ImpellersPitched-bladeRushton-typePitched-blade
Gassing   
Gas supplyTMFC; overlay and/or spargerTMFC/Rotameter; spargerTMFC; overlay and/or sparger
Standard gas flow rates0.1 – 50 sL/h, 0.1 – 40 sL/h CO2 (DASGIP MX4/4, other modules available)0.5 – 250 sL/h, 0.5 – 150 sL/h CO2 (DASGIP MX4/4H, other modules available)0.5 – 250 sL/h, 0.5 – 150 sL/h CO2 (DASGIP MX4/4H, other modules available)
Standard gas mixingAir, N2, O2 and/or CO2Air, N2, O2 and/or CO2Air, N2, O2 and/or CO2
Feeding   
Feed lines per vesselUp to 8Up to 8Up to 8
Standard feed rates (depending on tube diameter)0.3 – 9.5 mL/h to 13 – 420 mL/h (DASGIP MP8) 10 – 70 mL/h to 0.4 – 5 L/h
(DASGIP MP4)
0.3 – 9.5 mL/h to 13 – 420 mL/h (DASGIP MP8)
10 – 70 mL/h to 0.4 – 5 L/h (DASGIP MP4)
0.3 – 9.5 mL/h to 13 – 420 mL/h (DASGIP MP8)
10 – 70 mL/h to 0.4 – 5 L/h (DASGIP MP4)
Monitoring and Control   
Temperature controlHeat blankets (optional cooling fingers)/ heating and cooling integrated in DASGIP BioblockHeat blankets (optional cooling fingers)/ heating and cooling integrated in DASGIP Bioblock (additional cooling fingers optional)Heat blankets (optional cooling fingers)/ heating and cooling integrated in DASGIP Bioblock (additional cooling fingers optional)
Standard temperature range (at 25° C room temp.)5 K above cooling agent temperature – 60°C (heat blankets)/ 5 K above cooling agent temperature – 99°C (DASGIP Bioblock)15 K above cooling agent temperature – 60°C (heat blankets/ 5 K above cooling agent temperature – 99°C (DASGIP Bioblock)15 K above cooling agent temperature – 60°C/ 5 K above cooling agent temperature – 99°C (DASGIP Bioblock)1
pH controlAcid and/or base, and other set-upsCO2/base, and other set-ups
DO controlCascade (O2 concentration, gas flow rate), and other set-upsCascade (agitation speed, optional O2 concentration, optional gas flow rate), and other set-upsCascade (O2 concentration, gas flow rate), and other set-ups
ORP (redox) measurement-OptionalOptional
Level/foamOptionalOptionalOptional
OD measurementOptional
(DASGIP OD4)
Optional
(DASGIP OD4)
Optional
(DASGIP OD4)
Exhaust condensationWater-cooled or liquid-free (Peltier with DASGIP EGC4)Water-cooled or liquid-free (Peltier with DASGIP EGC4)Water-cooled
Exhaust analysisOptional
(DASGIP GA4)
Optional
(DASGIP GA4)
Optional
(DASGIP GA4)
1Application-specific operating conditions apply.